Clone - The Road to Dolly, & the Path Ahead

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Clone - The Road to Dolly, & the Path Ahead
Gina Kolata
Manufacturer: New York: William Morrow & Company, Inc. 1998
ProductGroup: Book
Binding: Hardcover
ASIN: B000NVCKPE

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Clone - The Road To Dolly, And The Path Ahead -
Gina Kolata -
Manufacturer: William Morrow Publishing -
ProductGroup: Book
Binding: Hardcover
ASIN: B000O059UC

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Clone the Road To Dolly & the Path Ahead
Gina Kolata
Manufacturer: PENGUIN PUTNAM * TRADE
ProductGroup: Book
Binding: Paperback
ASIN: B000SHNTEY

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CLONE: THE ROAD TO DOLLY AND THE PATH AHEAD
GINA KOLATA
Manufacturer: PENGUIN
ProductGroup: Book
Binding: Hardcover
ASIN: B000S84JU6

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Clone: The Road to Dolly and the Path Ahead
Gina Kolata
Manufacturer: ALLEN LANE
ProductGroup: Book
Binding: Hardcover
ASIN: B000OLJ6K0

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pros and cons of a science-for-general-audience book

One Big Yawn

A Tale of Science & Myth on the 'road to Dolly'.

Interesting but too sensationalistic

Evenhanded, but little on real clones (identical twins)

Clone: The Road to Dolly and the Path Ahead
Gina Kolata
Manufacturer: Harper Perennial
ProductGroup: Book
Binding: Paperback

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Understanding Cloning (Science Made Accessible)

The Kite Runner

ASIN: 0688166342

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In February 1997 a group of Scottish livestock scientists announced that they had cloned a lamb using a cell from an adult sheep. "When the time comes to write the history of our age, this quiet birth, the creation of this little lamb, will stand out," says award-winning science writer Gina Kolata. In Clone, she gives a clear account of the technical background to Dolly's birth, but what makes the book really shine is her coverage of the history and social conflicts of cloning. She weaves stories of fraud, scandal, irreproducible results, and pig-headed determination into a solid framework of philosophy, science, and ethics.

Book Description

The birth of Dolly -- the world's first clone -- placed in our hands the secret of creation. Few discoveries have so altered our notion of what it means to be human, or presented such a Gordian knot of ethical, spiritual, and scientific questions. Noted science journalist Gina Kolata broke the news nationally in The New York Times and was the first reporter to speak with Dr. Ian Wilmut, the embryologist who cloned Dolly. Now Kolata reveals the story behind Dolly, interweaving the social and cultural tales of our fear and fascination with cloning, reaching back nearly a century, with the riveting scientific accountof how a clone came to be and the mind-boggling questions Dolly presents for our future.

Clone is a compelling blend of scientific suspense, dreams dashed, and frauds exposed, with provocative philosophical questions and an astute assessment of why Dolly's birth was only possible now. Like The Making of the Atomic Bomb, Lucy, and Chaos, this book gives us a window on history in the making, and an understanding of its profound effect on our lives.

Customer Reviews:

pros and cons of a science-for-general-audience book.......2005-01-08

This book shows a typical pros and cons of a science-for-general-audience type of book. Kolata, one of the most famous author in this field, offers numerous numbers of intriguing anecdotes in the peripheral realm of cloning. For instance, I found the Karl Ilmensee affair quite Intriguing , and a question like "what if a newspaper breaks the embargo policy of Nature (which happened)?" was answered to my satisfaction.

However, no story sheds much light on the central issue of biology. I would not be surprised if many general readers of this book would think that the purpose of the cloning of sheep was to generate some artificial protein in non-human live stock. Three technologies developed in 80's and 90's, namely recombinant protein expression, transgenic animal, and cloning are very confusing for non-scientists lay persons, but author never try to disentangle this confusions.

For me, I wish Kolata took a further step to provide some coherent hypothesis to explain the fundamental nature of this eureka event, as she has a good background in humanities. This type of the once-in-a-decade discovery has a nature to defy the conventional thought prevailing the era. Almost no developmental biologists thought the chromosome from somatic cells of adult mammal could gain totipotency by such a "primitive" method. Why can some scientist have the insight, while others can't? Is this a necessary byproduct of what Kuhn called paradigm? Or could this be at least an partial evidence of the relativism or instrumentalism advocated by WV Quine, or some other social contructivist? (or just a serendipitous application of "Don't worry Principle" that Sydney Brenner called?)

Neverthless, Kolata shows a great story-telling skills and I would recommend this book.

One Big Yawn.......2001-07-13

As a biochemistry major I was very excited about reading this book. I expected it to have in depth details on cloning and mention true clones such as identical twins. What a disappointment. The book went on and on for numerous pages about the ethical ramifications of cloning (yes, those exact same ethical ramifications TV and newspapers dealt with ad nauseam). Which yes, are important, but not enough to drone on about especially after readers have heard them all 10 times before. I actually found myself sighing and rolling my eyes over some of the ethical stances that were mentioned because they were so silly. I continued reading the book for a while in hopes that it would get better. It didn't. I finally threw the book under my bed (the black hole of bookdom) without ever finishing it.

A Tale of Science & Myth on the 'road to Dolly'........2000-10-04

Looking for an accessible guide to cloning together with sex, scandal, a putative hoax, a fraud claim, counterclaims, industrial secrets and a cast of maverick scientists and myths that makes for a greatly entertaining true story ? To find a single book which has the potential to affect one's ideas and thoughts as to what it means to be human is a rarity, but some readers might be so affected by this work. Thematically weaving between the key historical developments leading to claims for the first cloning success using adult tissue and discussions of the moral ethics of whether and why such research be conducted, Kolata's account of the making of `Dolly' the sheep reminded me of Watson's `The Double helix'. Not only do we read here about the manipulation of genetic material outside the realms of human replication and fertility, we are continually provoked with the wider issues relating to food production processess, the social responsibilies of the research scientist, and the role of science journalism in informing public opinion.We are also exposed to the less attractive side of running the day-to-day life of the research laboratory - the struggle with grant competition; peer pressure, review and publication demands; conference attendance and institutional sponsor politics. Kolata provides all of this in a very well written and researched book including frank (and seemingly) honest biographies of the leading players in the `road to Dolly'. The story as presented here covers a period of just over one hundred years following Weismann's discovery of the `loss of information' with subsequent cellular differentiations of dividing tissue. Within twenty years or so the role of the cell nucleus had been determined, and by 1938, Spemann's `Embryonic Development and Induction' proposed the very nuclear transplant experiment that was to succeed some 60 years later. The first successful accounts of this technique involved the use of the embryonic frog tissue in the 1950s by Briggs & King, but the older, more differentiated cell' nuclei proved harder to handle and maintain. In the early 1960s, Gurdon succeeds with the transfer of what were thought to be adult, fully differentiated cells taken from amphibian intestines. At about the same time as these developments were unfolding, the first symposia to address the possibility of cloning and its implications for ethics had taken place. The end of the 1960s had seen the advent of gene isolation (though curiously little is said about the discovery of DNA itself and the significance of the newly founded growth area of molecular biology) and within the next ten years we had moved from the in vitro fertilisation of mice to Louise Brown, born in 1978. That same year saw the publication of a non-fiction book claiming that the real-life `rich, eccentric Max' has himself cloned with the assistance of a World renown scientist known by the pseudonym `Darwin' with the assistance of a seventeen year old virgin called `sparrow', who gives birth to a healthy baby boy. I would recommend reading Kolata for her retelling of the Rorvik (1978) story if for no other reason. The following year saw Illmensee claim to have cloned the first mice using the nucleus of embryonic stem cells and, again, we are both entertained and informed by Kolata's telling of this most remarkable tale of intrigue and collegiate suspicion of happenings in the laboratory. It was not until the 1980s` and 90s that successful sheep, cow and eventually monkey cloning was to be completed (all still using embryonic nuclear material transfer) at least suggesting that there was no in principle reason to believe adult cloning to be beyond possibility. However, very few scientists apparently held this latter belief - and these few were not encouraged to pursue their ideas. Now suitably brought up to speed with our history of embryology, experimental biology techniques and the sweat involved in conducting seemingly unglamorous basic laboratory science, we are finally introduced to Ian Wilmut, whose research group were to achieve what to many was still `biologically impossible'. Wilmut and his colleage Campbell postulated that the problem of cloning transplants was perhaps with tranfering the nuclear DNA at such a time inappropriate to the natural activity phases of the cell cycle. Campbell determined that the so colled G0 (G-nought) phase of the cell cycle was one of synchrony and, combined with the technique of halting induced by nutritional deprivation, thought that it was during this period that cell `reprogramming' would be more likely successful. In March, 1996 the first clones of a mammal (sheep) were born using differentiated embryonic cell nuclei, but their announcement was largely lost to the wider world outside that of a handful of agricultural scientists. However, in July of the same year, the first sheep cloned from the fully-differentiated cell nuclei of adult tissue was born to Wilmut's lab. However, the news that was to reach the world over had first to wait out a period of great secrecy and gossip-mongering. The (true) story is revealed lucidly here, and provides another reason to read Kolata's book. And yes, in this account she was named for Dolly Parton.

Interesting but too sensationalistic.......1998-10-07

Clone: The Road to Dolly... is an interesting book outlining the research that contributed to the creation of the first mammalian clone and its philosophical implications.

There is much in the book to recommend it. It places the work in its correct historical context by describing the chain of discoveries, beginning with those in the early part of this century, that eventually led to Dolly.

However, the book is needlessly sensationalistic in the way it describes science and scientists, seeming to draw parallels with the worlds of power politics and showbiz. Science is really a more subdued and low-key affair - as exemplified by the very lab that created Dolly.

My major objection is that the book appears to take as its underlying assumption that the public (or a large segment) is opposed to science and treats its acheivements with profound suspicion. I agree that there exists a vocal minority that thinks this way and may have its roots in various fundamentalist movements. However, the majority of people that I have met, while frequently poorly informed, are not antagonistic to science, but rather are interested in enjoying the fruits of its labor. This may be why, as the book says, while various self-styled experts debate the ethics of cloning, infertile couples are lining up for possible medical applications. It is only when the public is either denied the benefits of science, or is not educated about what these benefits may be, that it grows resentful. This issue seems to have been overlooked. On the other hand, comparisons with the atomic bomb are abundant, though meaningless. The bomb has killed thousands and was created for that express purpose. Cloning has created very little and destroyed nothing, except a few egos.

Fortuneately, although the book begins grimly, it seems to end on a fairly optimistic note, moving away from its opening notions that cloning is an evil, dirty business.

The bottom line is that whatever else it may do, cloning does not undermine human dignity. A person's dignity arises from his or her actions, not whether they were born as a twin, testtube baby or clone. We would do well to remember that. To my mind, the most profound line in this book full of lines that compete for that honor is one attributed to a Scottish farmer who says, in some perplexity, 'I don't understand the big deal. A sheep is still a sheep.'

Evenhanded, but little on real clones (identical twins).......1998-09-21

The author of this book is mostly evenhanded; she clearly describes almost all the points of view about human cloning, no matter how profound or silly. However, she almost completely ignores the consensus viewpoint of most identical twins, triplets, and quads.

Identicals are a significant minority population, real human clones who view the entire cloning debate as silliness at best and bias against identicals at worst. Some societies used to kill identicals at birth, viewing them as evil!

No book about cloning is complete without serious consideration of living identicals.

Book Description

This digital document is an article from Issues in Science and Technology, published by National Academy of Sciences on March 22, 1998. The length of the article is 1889 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Clone: The Road to Dolly, and the Path Ahead. (book reviews)
Author: Robert Cook-Deegan
Publication: Issues in Science and Technology (Refereed)
Date: March 22, 1998
Publisher: National Academy of Sciences
Volume: v14 Issue: n3 Page: p90(5)

Article Type: Book Review

Distributed by Thomson Gale

Book Description

Slim, stylish and pocketable, Florence Directions is full of ideas for stop-overs, long-weekends and flying visits to one of Italy''s most popular city break destinations, richly illustrated with hundreds of specially commissioned photos. The full-colour introduction features 28 themed spreads - from the city''s frescos to the pick of the wine bars, among the best in all of Italy. The main section of the guide, "Places", gives a district-by-district account of the accommodation, sights, restaurants, shops, transport links and nightlife - all generously illustrated. Every listing and review is pinpointed on accompanying user-friendly maps.

Customer Reviews:

The Rough Guides' Florence Directions 1 (Rough Guide Directions) .......2007-01-08

It is a great book and with many information. What is missing are some maps that you will need when you are there.

Book Description

Twenty years after the last summary publication on the region, this volume presents the most complete modern summary of the latest surveys and research on all the birds now found in the Thai-Malay Peninsula. Over 380 species are described using data derived from field and museum research, as well as previously unpublished or poorly distributed data from local compilers, diaries, and personal records. More than 70 spectacular full-page color plates show almost all of the species covered. This volume also includes a fully referenced bibliography of over 800 sources. An extensive introduction covers aspects of history, biogeography, and ecology of the region's birds, plus main conservation issues.

Key Features:

Over 380 species are described in modern handbook format using data derived from field and museum research
The only detailed handbook of the birds of the region; supplies a benchmark synopsis (first in 20 years) of the bird fauna and ornithological research in the Peninsula, much of it published for the first time.
Over 70 color plates
Many species illustrated for the first time
Serves as an introductory text which describes the region and its conservation crisis

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Illuminates why it can be important to improve the quality of metamodels by using even modest phenomenological knowledge to help structure them.

Motivated Metamodels: Synthesis of Cause-Effect Reasoning and Statistical Metamodeling

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From...........2001-03-02

Yoga in the Morning, Martini at Night or the First Three-Score > and Ten Are the Hardest > by Carol L. Winfield

"Ms Winfield, Maine-born in 1918, autobio's her long, sometimes joyous, sometimes difficult, life to date. She tells us her many attempts to survive happily, some of them totally wrong, some of them successful. But by now she has learned all the techniques. She passes them on to us with thoughtfulness, humor, and many shrewd observations. We, the increasing number of octogenarians, must read and profit by her regime of vigorous exercise, well rounded diet, yoga, meditation, active participation in community life, teaching, working, and coming home to relax at night, with a Martini (singular, you notice), a good book, a fine recording, or a recommended video. We who wish to thoroughly enjoy these last 3 or 4 decades should thoughtfully study her recipe for successful

Third Aging and act accordingly. I give it all five stars."

Book Description

Thirkell's last, unfinished novel, completed by her close friend C. A. Lejeune, features a host of new and old friends from the author's beloved Barsetshire. This time out, a little boy appears to save Wiple Terrace, home of Miss Hampton and Miss Bent, from destruction. The budding romance between Lord Mellings and Lavinia Merton flowers, a past love finds Dr. Ford, and the Old Bank House provides the setting for the final scene, an all-Barsetshire party to celebrate the 70th birthday of Mrs. Morland, the popular novelist.

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Not Quite Our Angela.......2005-09-18

Three Score & Ten is the last in Angela Thirkell's famed Barsetshire series of novels. Ms. Thirkell died before finishing it, and it was finished by one of her friends. The difference shows, and it is instructive. Angela Thirkell was the mistress of light, slightly ironic prose. The world her characters inhabited probably seemed old fashioned sixty years ago when she wrote them. Her style was uniquely her own. She seemed to go off on tangents (divigations, she called them) yet they always illuminated her characters and the story she was telling. The divigations are here but instead of a souffle lightness, they are heavy and show the effort that went into them. The characters are not quite as silly and literate as they were when Thirkell's effortless erudition created their dialogue. Still, this is Barsetshire, and all the familiar faces are here--for what clearly Thirkell herself knew would be the last time.
Even though not vintage Thirkell, such a visit is well worth the time.

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Give Us This Day Three Score Years And Ten

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