Wcsworking Papers for Fresno City College

Average customer rating:
Superlccs 2001 Schedule Ke (SUPERLCCS: Gale's Library of Congress Classification Schedules Combined with Additions ... (40 Vol.))

Manufacturer: Gale Group
ProductGroup: Book
Binding: Hardcover

General | Law | Subjects | Books
General | Law | Professional & Technical | Subjects | Books
ASIN: 0787642142

Book Description

There is a vast range of astronomical equipment available to the amateur astronomer and this pocket-sized handbook will help the amateur make an informed choice about which instruments are best suited to his or her needs covering binoculars, telescopes, eyepieces, filters, and motors. All selection criteria are taken into account, such as level of experience, budget, and observation site. This handbook will help complete beginners make their first purchases, and provide advice for more experienced amateurs wishing to upgrade their equipment. Hervé Burillier runs his own specialist astronomy bookshop in Vannes, France, stocking over five hundred titles. He is a member of the French Astronomical Society (SAF) and of the French Association of Variable Star Observers, and has written the column Observing the Sky in L'Astronomie (the monthly publication of the French Astronomical Society) since 1990. Christophe Lehenaff is an experienced amateur astronomer and specialist on astronomical equipment. He is the author of several French astronomy books.

Customer Reviews:

A Practical Guide for Beginners .......2005-09-20

I've always had an interest in astronomy, but I never bought a telescope. Finally, when I more seriously considered taking the plunge, I quickly realized that there was a great deal that I didn't know about the variety of observing equipment that's out there, how it works, the pros and cons of each design, how to use it, accessories, prices, etc. I needed a guide that would answer all of my questions in a manner that is clear, simple, short and to the point. This little book (128 pages) seemed to be exactly what I needed, so I bought it. I was not disappointed. Everything seems to be covered, from different telescope optical designs, types of mounts, variety of accessories, etc., to associated software packages and useful publications. Throughout the book, the reader's budget is kept in mind - prices are indicated to give the reader some perspective. The text is very clear and concise and many figures and photos complement it very nicely. I recommend this book to anyone who, like me, wants to gain basic knowledge of the equipment that is out there for use in amateur astronomy - knowledge that could be most useful in making an informed decision as to which equipment to purchase.

Book Description

Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.

Customer Reviews:

A Primary Sourcebook for Chemotherapists.......2000-04-03

This an extremely sophisticated analysis of one of the most troubling aspects of chemotherapy, namely the tendency over time for a patient to develop resistance to the agent being applied. The Goldie-Coldman model for resistance is one of the best known in chemotherapy. Since it operates at a level of some mathematical complexity, some physicians and biochemists have found it somewhat off-putting. However, in this book, the authors have carefully minimized mathematical complexity and emphasized an intuitive approach which is very approachable by most oncologists. This book is an excellent resource, one which should be in the library of every chemotherapist,

Preclinical and Clinical Modulation of Anticancer Drugs (Handbooks in Pharmacology and Toxicology)

Average customer rating:

Preclinical and Clinical Modulation of Anticancer Drugs (Handbooks in Pharmacology and Toxicology)
Kenneth D. Tew , Peter J. Houghton , and Janet A. Houghton
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

General | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

General | Health, Mind & Body | Subjects | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

Medicine | Qualifying Textbooks - Fall 2007 | Stores | Books

Professional | Qualifying Textbooks - Fall 2007 | Stores | Books
ASIN: 0849372917

Book Description

Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.

Alternative Mechanisms of Multidrug Resistance in Cancer

Average customer rating:

a state of the art in cancer multidrug resistance mechanisms

Alternative Mechanisms of Multidrug Resistance in Cancer
John A. Kellen
Manufacturer: Birkhauser
ProductGroup: Book
Binding: Hardcover

General | Science | Subjects | Books

General | Pharmacology | Medicine | Subjects | Books

General | Research | Medicine | Subjects | Books

Nursing | Medicine | New & Used Textbooks | Stores | Books
ASIN: 0817637753

Customer Reviews:

a state of the art in cancer multidrug resistance mechanisms.......1997-05-18

That cancer cell is a complex evolving creature is by now a well-known fact. The understanding of this complexity, although painfully scarce, is not an elusive goal, as in the future, in one way or another, all the therapeutical approaches will rely on this understanding. A current trend in pharmaceutical research and anti-cancer drug design is the discovery of new and new drugs with the hope that one day, one unique drug or a combination of drugs will be able to interrupt or to reverse any potentially malignant process. The same is true about anti-HIV therapy, where every year new compounds are tested or approved, while drug or multidrug resistance seems impossible to be overcome and consequently it is left as it is. The image of cancer cell resistance to our therapeutical attempts would have been incomplete if Dr. Kellen would have not given us a new book, in continuation of the Reversal of Multidrug Resistance in Cancer. Alternative Mechanisms of Multidrug Resistance in Cancer expands our knowledge beyond P-glycoprotein, as the hobby horse mechanism in tumor drug and multidrug resistance. In the same time, the book is a scary panorama of what a cancer cell could become when it has to defend itself against the xenobiotical therapeutics trying to disturb its life and function. References to P-glycoprotein are succinct in this book but one should keep in mind that any of the "nonclassical" MDR mechanisms described here could be associated with an increased P-gp activity in the cancer cell. Some of these mechanisms seem to be specific to malignant cells exposed to chemotherapeutics; among these, MRP protein(s) and function, topoisomerase II and I associated MDR and X-irradiation induced MDR, are discussed in detail. A pleasant surprise is the chapter on taxoids in multidrug resistance, in an era when taxol and taxoid-derived drugs are a most efficient new weapon in previously incurable cancers. Other mechanisms are less specifically induced by cancer chemotherapy and belong to a more general defensive response of cells exposed to various noxious compounds(glutathione S-transferases, DNA repair enzymes induced by DNA-damaging agents) or have an indirect effect on MDR -protein kinase C, as a major player in intracellular signaling, in this way influencing some of the putative MDR mechanisms, or bcl-2, whose contribution to the malignant phenotype is by preventing cell death when this should normally occur. Although not conclusive, one of the final chapters is an attempt to gather under the same roof all these apparently dispersed mechanisms which are, without doubt, tightly interconnected at a molecular level. The book is written in a lively and convincing style. Even if it leaves many questions without an answer, as is the case of the significance of occurrence of all these MDR mechanisms in the living organism, it is a strong pleading for a research which, for the future of cancer therapy, would eventually become even more important than discovering or designing new antitumour agents.

Anticancer Drug Resistance: Advances in Molecular and Clinical Research (Cancer Treatment and Research)

Average customer rating:

Anticancer Drug Resistance: Advances in Molecular and Clinical Research (Cancer Treatment and Research)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

General | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

Book Description

Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.

Cancer Drug Resistance (Cancer Drug Discovery and Development)

Average customer rating:

Cancer Drug Resistance (Cancer Drug Discovery and Development)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

General | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

Book Description

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer (Contributions to Gynecology and Obstetrics)

Average customer rating:

Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer (Contributions to Gynecology and Obstetrics)
O. R. Kochli , and B. U. Sevin
Manufacturer: S. Karger AG (Switzerland)
ProductGroup: Book
Binding: Hardcover

General | Health, Mind & Body | Subjects | Books

General | Medicine | Subjects | Books

Generative Organs | Reproductive & Sexual | Medicine | Subjects | Books

Obstetrics & Gynecology | Specialties | Medicine | Subjects | Books

Chemosensitivity Testing in Oncology (Recent Results in Cancer Research)

Average customer rating:

Chemosensitivity Testing in Oncology (Recent Results in Cancer Research)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

General | Medicine | Subjects | Books

General | Biological Sciences | Science | Subjects | Books

All Amazon Upgrade | Amazon Upgrade | Stores | Books

Health, Mind & Body | Amazon Upgrade | Stores | Books

Medicine | Amazon Upgrade | Stores | Books

Professional & Technical | Amazon Upgrade | Stores | Books

Science | Amazon Upgrade | Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

Medicine | Qualifying Textbooks - Fall 2007 | Stores | Books

Professional | Qualifying Textbooks - Fall 2007 | Stores | Books

Science | Qualifying Textbooks - Fall 2007 | Stores | Books
ASIN: 3540434682

Book Description

The last decade has seen a renaissance of the concept of individualized chemotherapy in oncology, markedly stimulated by the development of new in vitro chemosensitivity assays. The clinical utility of drug response assays has been evaluated in clinical trials and the results suggest that assay-assisted therapy selection may improve survival as well as economic outcomes. This volume comprises the proceedings of the first Symposium of the International Society for Chemosensitivity Testing in Oncology, ISCO-1, held in Homburg/Saar, Germany, in September 2001. The topics include: new in vitro drug-testing methods, tumor chemosensitivity assays, and the clinical relevance of assay-directed therapy.

Clinically Relevant Resistance in Cancer Chemotherapy (Cancer Treatment and Research)

Average customer rating:

Clinically Relevant Resistance in Cancer Chemotherapy (Cancer Treatment and Research)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

Immunology | Basic Science | Medicine | Subjects | Books

General | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

All Amazon Upgrade | Amazon Upgrade | Stores | Books

Medicine | Amazon Upgrade | Stores | Books

Professional & Technical | Amazon Upgrade | Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

Medicine | Qualifying Textbooks - Fall 2007 | Stores | Books

Professional | Qualifying Textbooks - Fall 2007 | Stores | Books
ASIN: 1402072007

Book Description

The introduction of new anticancer drugs and drug combinations, as well as the use of high-dose chemotherapy with growth factor and hemopoietic stem cell support, has greatly increased clinical remission rates. Unfortunately palliation, rather than cure, remains the most realistic goal of chemotherapy for many patients. The failure to cure metastatic cancer is commonly attributed to drug "resistance". Resistance can be broadly viewed as the survival of malignant cells because of a failure to deliver an effective drug dose to the (cellular) target, resulting from any one of or combination of individual factors. For example, inter-individual genetic differences in drug metabolism, as well as differences in tumor kinetics and vascularization, may be important for treatment outcome. In addition, numerous molecular mechanisms of resistance have been elucidated at the level of the individual tumor cell.
The present volume reviews clinically relevant aspects of the pharmacokinetics of commonly used anticancer agents as well as mechanisms of cellular/experimental resistance to such agents. This extends to technological advances that enable high-throughput studies of genetic polymorphisms, which has opened up new avenues to the study of drug resistance and to the individualization of chemotherapy in order to decrease clinical toxicity and optimize treatment results.
"This text provides a comprehensive review of the mechanisms of resistance to cancer chemotherapuetic agents. Leading experts discuss molecular and biochemical pathways that influence cytotoxicity. Knowledge of these potential obstacles to therapy will allow for the development of more effective strategies to treat malignant diseases."
Steven T. Rosen, M.D., Series Editor

Cytotoxic Drug Resistance Mechanisms (Methods in Molecular Medicine)

Average customer rating:

Cytotoxic Drug Resistance Mechanisms (Methods in Molecular Medicine)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

General | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books
ASIN: 0896036030

Book Description

Leading clinical and laboratory scientists describe cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumors. The protocols contain detailed instructions and extensive troubleshooting tips that allow researchers effectively to study a wide variety of drug resistance mechanisms, including aspects of drug-induced cell death, drug uptake/efflux, drug metabolism, and DNA repair. Each method is designed to help identify the correlation between molecular and biochemical data and the clinical responses of the patient. Cytotoxic Drug Resistance Mechanisms illuminates all the clinically relevant mechanisms used as markers of the biological response to anticancer biotherapeutics today.

Average customer rating:

Drug Resistance

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

General | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

Book Description

Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.

Book Description

1Bimal D. Theophilus and Ralph Rapley provide biological and clinical investigators with a comprehensive collection of new, recent, and updated PCR-based screening methods suitable for detecting the presence of both known and novel mutations. The methods cover point mutations (e.g., ASO-PCR, SSCP, DGGE, chemical cleavage), deletions (multiplex PCR, FISH, blotting), non-sense mutations (PTT), and more. The new and exciting techniques of DNA array analysis, along with such recently developed experimental methods as conformation-sensitive gel electrophoresis, are also included. Each chapter explains the basic theory behind the technique and provides valuable notes essential for its successful execution.

Book Description

The Fledgling tells the story of an unmarried librarian whose life changes irrevocably when she invites a young pregnant girl into her home. First published in 1974, it describes the social climate and mores of Auckland during the 1950s.

The fledgling [by] Jane Langton (Novel units) (Novel units)

Average customer rating:

The fledgling [by] Jane Langton (Novel units) (Novel units)
Anne Troy
Manufacturer: Anne Troy and Phyllis Green
ProductGroup: Book
Binding: Paperback

General | Books & Reading | Literature & Fiction | Subjects | Books

General | Literature | Children's Books | Subjects | Books
ASIN: 1561376655

Books:

Books Index

Books Home

Recommended Books